ebiom+

Genetic testing is clinically indicated for:

• Women who have difficulty conceiving
• Patients undergoing fertility treatment
• Patients experiencing embryo implantation failure during IVF
• Patients who experience recurrent miscarriage
• Patients with unexplained infertility

Results can help:

• Identify beneficial and harmful bacteria in the endometrial microbiome for precise diagnoses (including pathogenic bacteria associated with CE)
• Detect microbiome imbalances linked to embryo implantation failure and infertility
• Guide targeted use of probiotics or antibiotics for better patient care
• Improve fertility care

The report provides information about the bacterial composition of the endometrial microbiome. Here’s an example

Evaluation of lactobacillus: Percentage of Lactobacillus, e.g., 50% Lactobacillus spp. The administration of probiotics should be considered.

Evaluation of other bacteria: Percentage of other bacteria, e.g., 5% Prevotella spp. To date, no advantages or disadvantages have been described for Prevotella spp. in connection with fertility treatment.

Evaluation of potential pathogenic bacteria: Percentage of pathogenic bacteria, e.g., 45% Gardnerella spp. Any potential treatment should follow guideline recommendations.

Summary of the results and recommendations: In this case, treatment with metronidazole and clindamycin would be based on the guidelines for bacterial vaginosis.

If the results indicate an altered microbiome or the presence of potentially pathogenic bacteria, treatment options may include:

Probiotic treatment
The most important lactobacilli for maintaining a healthy vaginal flora and supporting fertility are Lactobacillus crispatus and Lactobacillus gasseri, followed by Lactobacillus jensenii and Lactobacillus rhamnosus. These bacteria contribute to the body’s defense against pathogenic microorganisms through various mechanisms, including the production of H2O2, providing an additional layer of protection alongside the immune system.

To support the natural flora of the female genital tract, supplements containing L. crispatus, L. rhamnosus, L. acidophilus, L. gasseri, and L. fermentum have been found effective in patients experiencing dysbiosis. Source: S2k Guideline on Bacterial Vaginosis, AWMF Registry Number 015-028

Antibiotic treatment
Since susceptibility testing can’t be performed using traditional methods (antibiogram) due to technical reasons, treatment recommendations follow established guidelines. For instance, bacterial species identified in relation to bacterial vaginosis can be treated with clindamycin or metronidazole, according to the S2k Guideline on Bacterial Vaginosis. If intracellular pathogens like Chlamydia, Mycoplasma, or Ureaplasma are detected, doxycycline is recommended.

To ensure an accurate assessment of treatment effectiveness, both probiotic and antibiotic therapies should be discontinued at least one week before a follow-up test.

In our laboratory, we utilise cutting-edge techniques to guarantee that our clients receive accurate, advanced diagnostic results.

• technologies offer a reliable and highly sensitive diagnostic method, enabling cost-effective, parallel sequencing of multiple genes with high analytical depth and scalability.
• provides a targeted and highly sensitive diagnostic approach, enabling the simultaneous amplification and detection of multiple genetic variants in a single assay with rapid turnaround and high analytical accuracy.