Prostate Cancer

Synonyms: -

Material:

FFPE tissue sections

TAT:

varies depending on the analysis

Method:

NGS

Overview

Prostate cancer accounted for approximately 1.55 million new cases worldwide in 2024, representing 7.5% of all newly diagnosed cancers and making it the fourth most commonly diagnosed cancer globally. The WHO Classification describes the morphological and molecular features of prostatic tumours, while clinical guidelines address the use of molecular testing for prognosis and treatment selection. In routine practice, the diagnosis and classification of most prostate carcinomas remain primarily histomorphological. Molecular and biomarker testing has its greatest established clinical relevance in advanced disease, where it can identify alterations associated with targeted or tumour-agnostic treatment options.

Clinical background and relevance

Available tests

The sequencing and the fusion gene analysis listed below can be ordered individually or together as one combined analysis.

This analysis focuses on selected treatment-relevant genes and does not constitute comprehensive genomic profiling. Depending on the clinical setting, additional testing may be indicated, including analysis of CDK12, assessment of PTEN expression, tumour mutational burden (TMB), MMR protein expression, germline testing, or broader DNA/RNA profiling.

Single-method analysis	Panel	Gene scope	Purpose
Sequencing	Panel00751	ATM, BRAF, BRCA1, BRCA2, CHEK2, FANCA, PALB2, RAD51D	Detection of sequence variants in tumour tissue
Fusion gene analysis	Panel00749	NTRK1, NTRK2, NTRK3	Detection of gene fusions in tumour tissue
Microsatellite instability (MSI)	Panel00750	Microsatellite marker analysis	Determination of tumour MSI status

Combined analysis	Panel	Gene scope
Combined focused analysis	Panel00541	ATM, BRAF, BRCA1, BRCA2, CHEK2, FANCA, PALB2, RAD51D, NTRK1, NTRK2, NTRK3

Additional tumour analyses, including TMB assessment and an assay-specific HRD or genomic-instability assessment, are available as part of Panel00617 ().

Therapy

References

Created by

Our editorial team consists of medical specialists and scientists in the field of human genetics. All content is created and reviewed in accordance with current scientific standards.

Last Update : 24.09.2026

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