ForeSENTIA: Pan-Cancer Core

Synonyms: -
Material
Material:
FFPE tissue sections
Untersuchungsdauer
TAT:
2-3 weeks
Contact
Methode
Method:
NGS
Overview

The ForeSENTIA Pan-Cancer Core panel analyses single nucleotide variants, insertions, deletions, copy number alterations, and rearrangements in 80 genes associated with different types of cancers. It can help identify mutations that can be responsible for cancer development and therapy resistance in solid tumours. The clinical significance of the genes tested has been previously emphasised by professional bodies including NCCN and ESMO. Depending on the type of cancer and the genetic alterations identified, different FDA/EMA-approved drugs as well as eligible clinical trials are available.

Microsatellite instability (MSI) immunotherapy biomarker is also tested in this panel. FDA/EMA-approved immunotherapies, such as pembrolizumab, are also available for patients with MSI-high status depending on their type of cancer.

ForeSENTIA: Pan-Cancer Core
80 Gene(s)*
AKT1
ALK
APC
AR
ARAF
ATM
ATRX
BARD1
BRAF
BRCA1
BRCA2
BRIP1
CDH1
CDKN2A
CHEK2
CIC
CTNNB1
DDR2
DICER1
EGFR
ERBB2
ERBB3
ERBB4
ESR1
FBXW7
FGFR1
FGFR2
FGFR3
FLT3
FOXA1
FOXL2
FUBP1
GATA3
GNA11
GNAQ
GNAS
H3F3A
IDH1
IDH2
JAK2
KEAP1
KIT
KRAS
MAP2K1
MAP3K1
MET
MLH1
MRE11
MSH2
MSH6
MTOR
MYC
MYCN
NBN
NF1
NPM1
NRAS
NTRK1
NTRK2
NTRK3
PALB2
PDGFRA
PIK3CA
PIK3CB
PMS2
POLE
PTEN
RAD51C
RAD51D
RAF1
RB1
RET
ROS1
RUNX1
SMAD4
SPOP
STK11
TERT
TMPRSS2
TP53


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