ForeSENTIA: Gene-Focused IDH1 & IDH2

Synonyms: -
Material
Material:
FFPE tissue sections
Untersuchungsdauer
TAT:
2-3 weeks
Contact
Methode
Method:
NGS
Overview

The ForeSENTIA IDH1 and IDH2 Gene-Focused Panel tests for single nucleotide variants, insertions and deletions on the IDH1 and IDH2 genes. IDH1 and IDH2 are genes transcribed into metabolic enzymes responsible for converting isocitrate to α-ketoglutarate. This protein is essential in cell metabolism, regulation of cell signalling pathways, and cell proliferation.

In cancer, they were found to be frequently mutated resulting in abnormal cell signalling regulation, and cell proliferation of cancerous cells. Some examples of cancers caused by mutations in IDH1/IDH2  include glioblastomas, cholangiocarcinomas, and others.

Different drugs against IDH1 and IDH2 are currently being studied for their efficacy in different types of tumours. One drug that was recently approved by the FDA is ivosidenib, which targets IDH1 in cholangiocarcinoma patients.

ForeSENTIA: Gene-Focused IDH1 & IDH2
2 Gene(s)*
IDH1
IDH2


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Our editorial team consists of medical specialists and scientists in the field of human genetics. All content is created and reviewed in accordance with current scientific standards.

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