ForeSENTIA: Breast / Gynecological

Synonyms: -
Material
Material:
FFPE tissue sections
Untersuchungsdauer
TAT:
2-3 weeks
Contact
Methode
Method:
NGS
Overview

The ForeSENTIA Breast/Gynaecological panel tests for single nucleotide variants, insertions, deletions, copy number alterations, and rearrangements in 48 genes which are commonly found in gynaecological cancers such as breast, ovarian, and others. Different risk factors can contribute to the development of gynecological cancers such as inheritance, increase in age, and environmental factors. Identifying the genetic alterations that can contribute to cancer progression can help in therapy selection and re-evaluation. There are numerous FDA/EMA-approved therapies for gynecological cancers depending on the type of cancer and the mutations identified.

Microsatellite instability (MSI) immunotherapy biomarker can optionally be in this panel. The FDA-approved immunotherapy drug pembrolizumab is also available for treating patients with MSI-high status. Pembrolizumab has also been approved by the EMA for endometrial cancer.

ForeSENTIA: Breast / Gynecological
48 Gene(s)*
AKT1
ATM
BARD1
BRAF
BRCA1
BRCA2
BRIP1
CHEK2
CTNNB1
DICER1
EGFR
ERBB2
ERBB3
ESR1
FBXW7
FGFR1
FGFR2
FGFR3
FOXA1
FOXL2
GATA3
KIT
KRAS
MAP3K1
MET
MLH1
MRE11
MSH2
MSH6
MTOR
NBN
NRAS
NTRK1
NTRK2
NTRK3
PALB2
PIK3CA
PIK3CB
PMS2
POLE
PTEN
RAD51C
RAD51D
RAF1
RET
RUNX1
SMAD4
TP53


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