ForeSENTIA: Gene-Focused BRAF

Synonyms: -
Material
Material:
FFPE tissue sections
Untersuchungsdauer
TAT:
2-3 weeks
Contact
Methode
Method:
NGS
Overview

ForeSENTIA BRAF Gene-Focused Panel tests for single nucleotide variants, insertions and deletions on the BRAF gene. BRAF is a gene found in chromosome 7 and it is transcribed into a serine/threonine protein kinase. This protein is essential in cell growth, regulation of cell signalling pathways, and cell division.

In cancer, the BRAF gene is frequently mutated resulting in abnormal regulation of the cell signalling pathways and ultimately uncontrolled growth of the cancer cells. Examples of cancers in which BRAF is found to be mutated are melanoma, NSCLC, colorectal, ovarian, glioma, and others. Different mutations of the BRAF gene have been observed in cancer patients. One of the most common is the V600E mutation and it is frequently found in melanoma, colorectal, thyroid, and other types of cancer.

There are several drugs that are currently used for certain tumours and target BRAF mutations. Some examples include vemurafenib, dabrafenib, and encorafenib.

ForeSENTIA: Gene-Focused BRAF
1 Gene(s)*
BRAF


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