NeoThetis: Lung (NSCLC)

Synonyms: -
Material
Material:
Blood in STRECK tube
Untersuchungsdauer
TAT:
6-9 days
Contact
Methode
Method:
NGS
Overview

According to World Health Organisation, lung cancer is the second most common type worldwide, with more than 2 million cases in 2020. Non-small cell lung cancer (NSCLC) is a type of lung cancer and accounts for 80-85% of all lung cancer cases. There are three types of NSCLC: adenocarcinomas, squamous cell carcinoma, and large cell carcinoma. These cancers originate from different types of lung cells depending on the cancer type. Different risk factors such as hereditary and environmental factors can contribute to NSCLC development. Mutations in driver genes, such as EGFR, ALK, and ROS1 among others, can lead to cancer initiation and progression. Detecting the genetic alterations that contribute to NSCLC can help in identifying available /-approved targeted therapies which might contribute to improvement of the overall survival of cancer patients. This panel identifies the genetic mutations in 36 genes in the circulating tumour DNA.

Microsatellite instability (MSI) immunotherapy biomarker is also tested in this panel. The -approved immunotherapy drug pembrolizumab is applicable for patients with MSI-high status.

NeoThetis: Lung (NSCLC)
36 Gene(s)*
AKT1
ALK
APC
ARAF
ATM
BRAF
BRCA2
CTNNB1
DDR2
EGFR
ERBB2
ERBB3
ERBB4
FBXW7
FGFR1
FGFR2
FGFR3
JAK2
KEAP1
KRAS
MAP2K1
MET
NRAS
NTRK1
NTRK2
NTRK3
PDGFRA
PIK3CA
POLE
PTEN
RAF1
RET
ROS1
SMAD4
STK11
TP53


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