NeoThetis: Gastric

Synonyms: -
Material
Material:
Blood in STRECK tube
Untersuchungsdauer
TAT:
6-9 days
Contact
Methode
Method:
NGS
Overview

Gastric cancer is a type of cancer that initiates from the cells in the lining of the stomach. Different factors, such as environment and inheritance, can increase the risk of developing gastric cancer. Accumulation of mutations can result in the transformation of healthy cells into cancerous cells that will divide uncontrollably, forming a tumour mass. At advanced stages, the tumour can release circulating tumour DNA (ctDNA) in the blood which will contain all the genetic alterations responsible for cancer initiation and development. This panel identifies the genetic mutations in 23 genes in the ctDNA, which has many benefits, including better prognostic assessment as well as therapy selection guidance which is tailored to each patient.

Microsatellite instability (MSI) immunotherapy biomarker assessment is also included in this panel and has been shown to be implicated in gastric cancer. Evidence suggests that MSI high status is correlated with better prognosis in patients with gastric cancer as well as improved survival rates. The /-approved drug pembrolizumab can be used as an immunotherapy option for MSI-high patients with gastric cancer.

NeoThetis: Gastric
23 Gene(s)*
APC
CDH1
EGFR
ERBB2
FGFR1
FGFR2
FGFR3
KIT
KRAS
MET
MLH1
MSH2
MSH6
NF1
NTRK1
NTRK2
NTRK3
PDGFRA
PIK3CA
PMS2
SMAD4
STK11
TP53


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