PreSENTIA: Pan-Cancer

PreSENTIA Pan-Cancer panel is recommended for individuals who:

• Have a personal or family history of a hereditary cancer syndrome
• Have been diagnosed with a type of cancer before the age of 50
• Have several family members on the same side of the family with cancer
• Have family members with early cancer onset
• Have family members with rare cancer types
• Have family members with an unusual type of cancer (breast cancer in a male)
• Have a family member that has been diagnosed with a germline mutation associated with cancer susceptibility
• Have history of previous malignancies
• Belong in specific ancestry groups who have high risk for developing specific types of cancer (e.g Ashkenazi Jewish who have high risk developing breast or prostate cancer)

PreSENTIA Pan-Cancer panel includes screening for 24 hereditary cancer syndromes:

• Ataxia-telangiectasia syndrome (ATM)
• BAP1 mutation associated disease (BAP1)
• Constitutional mismatch repair syndrome (EPCAM, MSH2, MSH6, MLH1, PMS2)
• (DICER1)
• (APC)
• (FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, SLX4, ERCC4, BRCA1, BRCA2, BRIP1, PALB2, RAD51C)
• (BRCA1, BRCA2)
• (CDH1)
• Hereditary mixed polyposis syndrome (GREM1)
• Hereditary melanoma-pancreatic cancer syndrome (CDKN2A, CDK4)
• (SDHD, SDHAF2, SDHC, SDHB)
• (SMAD4, BMPR1A)
• (TP53)
• Li-Fraumeni syndrome 2 (CHEK2)
• (EPCAM, MLH1, MSH2, MSH6, PMS2)
• (MEN1)
• (RET)
• (MUTYH)
• (STK11)
• Polymerase proofreading associated syndrome (POLD1, POLE)
• (PTEN)
• (RB1)
• (VHL)
• Xeroderma Pigmentosum syndrome (DDB2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, POLH, XPA, XPC)

The above information was taken by professional bodies such as , and