Immunogenetics
Placing genetics at the core of medical decisions
Immunogenetics testing analyses immune-related genetic markers and histocompatibility factors, most commonly the human leukocyte antigen (HLA) system and, in selected contexts, killer-cell immunoglobulin-like receptor (KIR) genes.
These tests support clinical decision-making in areas such as transplantation, donor–recipient compatibility assessment, HLA disease association, pharmacogenomic safety screening, transfusion medicine, and post-transplant monitoring. In selected specialist settings, immunogenetic testing may also contribute to reproductive medicine assessment, where supported by clinical evidence and expert interpretation.
Unlike many genetic tests, immunogenetics testing does not usually aim to identify a single disease-causing variant. Results are typically interpreted as compatibility, association, susceptibility, immune-interaction, monitoring, or therapy-related risk information, depending on the clinical indication. They should not usually be interpreted in the same way as rare disease or monogenic variant results.
Testing is performed using validated methodologies and internationally recognised professional standards, including the standards of the .
Our genetic tests
Our immunogenetics portfolio includes a range of services such as HLA typing, KIR genotyping, crossmatch testing, chimerism analysis, HLA disease association testing, and HLA pharmacogenomics testing.
Test or service | Clinical application |
| HLA typing | Donor–recipient matching, transplant compatibility assessment, and selected disease association studies |
| Crossmatch testing | Evaluation of pre-transplant immune compatibility |
| Chimerism analysis | Monitoring donor and recipient cell populations after transplantation |
| KIR genotyping | Assessment of NK-cell receptor interactions in selected transplantation and reproductive medicine settings |
| HLA disease association testing | Supportive assessment of selected immune-mediated or inflammatory conditions |
| HLA pharmacogenomics testing | Therapy safety support for medicines associated with HLA-linked adverse reaction risk |
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Our editorial team consists of medical specialists and scientists in the field of human genetics. All content is created and reviewed in accordance with current scientific standards.
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